MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2

Figure 5

miR-429 promotes tumorigenesis in a LATS2 dependent manner. (a, b) Western blotting analysis of YAP/TAZ expressions in miR-429 mimics transfected RKO and HCT116 cells with or without LATS1/2 flag. (c) Expressions of the downstream molecules of YAP/TAZ, CTGF, CYR61, and ANKRD1 were affected by miR-429 and LAST1/2 accordingly. (d, e) The enhanced colony formation abilities of RKO and HCT116 cells by forced expression of miR-429 were retrieved by LAST1/2 overexpression.

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