Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components
Table 2
Associations of plasma selenium concentration with MetS and its componentsa.
Quartiles of plasma selenium concentrations (μg/L)
value for trendb
value
Q1, <82.36
Q2, 82.37-92.66
Q3, 92.67-103.52
Q4, ≥103.53
MetS
No. of cases/controls, /
304/320
301/320
278/319
396/320
Crude OR
0.76 (0.61-0.95)
0.76 (0.61-0.94)
0.70 (0.56-0.87)
1
0.027
0.007
Model 1
0.80 (0.60-1.07)
0.76 (0.57-1.03)
0.62 (0.46-0.83)
1
0.266
0.017
Model 2
0.79 (0.59-1.06)
0.75 (0.56-1.01)
0.61 (0.45-0.83)
1
0.218
0.015
Central obesity
No. of cases/controls, /
334/283
316/299
282/306
388/319
Crude OR
0.97 (0.78-1.21)
0.87 (0.70-1.08)
0.76 (0.61-0.94)
1
0.985
0.062
Model 1
0.98 (0.73-1.30)
0.90 (0.67-1.19)
0.67 (0.50-0.90)
1
0.751
0.032
Model 2
0.98 (0.73-1.31)
0.89 (0.67-1.19)
0.67 (0.50-0.89)
1
0.755
0.031
Hypertriglyceridemia
No. of cases/controls, /
235/387
235/385
224/368
333/382
Crude OR
0.70 (0.56-0.87)
0.70 (0.56-0.87)
0.70 (0.56-0.87)
1
0.001
0.001
Model 1
0.74 (0.59-0.93)
0.75 (0.60-0.94)
0.71 (0.57-0.90)
1
0.012
0.010
Model 2
0.73 (0.58-0.92)
0.74 (0.59-0.93)
0.72 (0.57-0.91)
1
0.008
0.009
Low HDL-C
No. of cases/controls, /
236/386
180/440
156/438
194/521
Crude OR
1.64 (1.30-2.07)
1.10 (0.87-1.40)
0.96 (0.75-1.22)
1
<0.001
<0.001
Model 1
1.47 (1.15-1.88)
1.06 (0.82-1.37)
0.89 (0.69-1.16)
1
0.001
0.001
Model 2
1.42 (1.11-1.82)
1.05 (0.81-1.35)
0.88 (0.68-1.15)
1
0.003
0.003
High blood pressure
No. of cases/controls, /
326/219
322/210
300/233
383/252
Crude OR
0.98 (0.78-1.24)
1.01 (0.80-1.28)
0.85 (0.67-1.07)
1
0.826
0.446
Model 1
1.05 (0.82-1.36)
1.00 (0.77-1.29)
0.83 (0.65-1.07)
1
0.480
0.315
Model 2
1.08 (0.84-1.40)
1.01 (0.78-1.31)
0.82 (0.63-1.05)
1
0.335
0.181
Hyperglycemia
No. of cases/controls, /
324/298
379/240
386/209
487/227
Crude OR
0.51 (0.41-0.63)
0.74 (0.59-0.92)
0.86 (0.68-1.08)
1
<0.001
<0.001
Model 1
0.57 (0.45-0.72)
0.82 (0.65-1.03)
0.92 (0.73-1.17)
1
<0.001
<0.001
Model 2
0.58 (0.46-0.73)
0.82 (0.65-1.04)
0.92 (0.72-1.17)
1
<0.001
<0.001
aOdds ratios (95% confidence intervals) for MetS were estimated by conditional logistic regression, and ORs (95% CIs) for central obesity, hypertriglyceridemia, low HDL-C, hypertension, and hyperglycemia were estimated by binary logistic regression. Model 1 was adjusted for sex, age (years), and body mass index (kg/m2). Model 2 was adjusted for model 1 plus smoking (current, former, and never), drinking (current, former, and never), vigorous activity (yes or no), and education level (none or elementary school, middle school, and high school or college). HDL-C: high-density lipoprotein cholesterol; MetS: metabolic syndrome; OR: odds ratio. bTests for linear trend were conducted by using the median value for each quartile and treating it as a continuous variable.
