Oxidative Medicine and Cellular Longevity

Research Article

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Table 3

Associations of SELENOP rs7579 polymorphism with MetS and its components^a.


	Controls, (%)	Cases, (%)	Crude OR (95% CI)	value	Adjusted OR (95% CI)^b	value

MetS
GG genotype	373 (57.9)	299 (54.3)	1		1
GA genotype	216 (33.5)	208 (37.7)	1.20 (0.94-1.53)	0.140	1.42 (1.06-1.91)	0.018
AA genotype	55 (8.5)	44 (8.0)	1.00 (0.65-1.53)	0.993	1.09 (0.67-1.78)	0.725
GA+AA genotype	271 (42.1)	252 (45.7)	1.16 (0.92-1.46)	0.204	1.35 (1.03-1.77)	0.033
Central obesity
GG genotype	320 (56.8)	342 (56.0)	1		1
GA genotype	196 (34.8)	219 (35.8)	1.05 (0.82-1.34)	0.723	1.37 (0.97-1.92)	0.072
AA genotype	47 (8.3)	50 (8.2)	1.00 (0.65-1.53)	0.983	1.06 (0.61-1.85)	0.843
GA+AA genotype	243 (43.2)	269 (44.0)	1.04 (0.82-1.31)	0.765	1.30 (0.94-1.78)	0.109
Hypertriglyceridemia
GG genotype	445 (57.8)	226 (53.8)	1		1
GA genotype	265 (34.4)	155 (36.9)	1.15 (0.89-1.49)	0.277	1.14 (0.86-1.50)	0.359
AA genotype	60 (7.8)	39 (9.3)	1.28 (0.83-1.98)	0.265	1.35 (0.85-2.13)	0.207
GA+AA genotype	325 (42.2)	194 (46.2)	1.18 (0.93-1.49)	0.186	1.18 (0.91-1.52)	0.218
Low HDL-C
GG genotype	476 (56.8)	194 (55.0)	1		1
GA genotype	294 (35.1)	128 (36.3)	1.07 (0.82-1.39)	0.627	1.16 (0.86-1.56)	0.331
AA genotype	68 (8.1)	31 (8.8)	1.12 (0.71-1.77)	0.630	1.25 (0.76-2.06)	0.376
GA+AA genotype	362 (43.2)	159 (45.0)	1.08 (0.84-1.38)	0.558	1.18 (0.89-1.55)	0.253
High blood pressure
GG genotype	285 (56.0)	284 (56.3)	1		1
GA genotype	188 (36.9)	177 (35.1)	0.95 (0.73-1.23)	0.672	1.01 (0.76-1.34)	0.938
AA genotype	36 (7.1)	43 (8.5)	1.20 (0.75-1.92)	0.452	1.37 (0.83-2.27)	0.214
GA+AA genotype	224 (44.0)	220 (43.7)	0.99 (0.77-1.26)	0.909	1.07 (0.82-1.40)	0.622
Hyperglycemia
GG genotype	227 (57.9)	443 (55.5)	1		1
GA genotype	126 (32.1)	296 (37.1)	1.20 (0.93-1.57)	0.167	1.23 (0.93-1.62)	0.144
AA genotype	39 (9.9)	59 (7.4)	0.78 (0.50-1.20)	0.251	0.76 (0.48-1.20)	0.241
GA+AA genotype	165 (42.1)	355 (45.5)	1.10 (0.86-1.41)	0.434	1.12 (0.86-1.44)	0.403

^aOdds ratios (95% confidence intervals) for MetS, central obesity, hypertriglyceridemia, low HDL-C, hypertension, and hyperglycemia were estimated by binary logistic regression. HDL-C: high-density lipoprotein cholesterol; MetS: metabolic syndrome; SELENOP: selenoprotein P. ^bAdjusted for sex, age (years), body mass index (kg/m²), smoking (current, former, and never), drinking (current, former, and never), vigorous activity (yes or no), and education level (none or elementary school, middle school, and high school or college).