Oxidative Medicine and Cellular Longevity

Research Article

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Table 4

Associations of plasma selenium concentrations with MetS and its components according to rs7579 genotypes^a.


	Quartiles of plasma selenium concentrations (μg/L)				value	value for interaction^b
	Q1, <82.36	Q2, 82.37-92.66	Q3, 92.67-103.52	Q4, ≥103.53	value	value for interaction^b

MetS						0.402
GG	0.66 (0.39-1.10)	0.83 (0.51-1.36)	0.71 (0.43-1.18)	1	0.371
GA	0.53 (0.27-1.04)	0.65 (0.33-1.29)	0.44 (0.22-0.86)	1	0.095
AA	0.36 (0.08-1.57)	0.67 (0.16-2.86)	1.28 (0.30-5.44)	1	0.396
Central obesity						0.710
GG	0.77 (0.42-1.44)	0.81 (0.45-1.46)	0.77 (0.42-1.41)	1	0.796
GA	1.02 (0.47-2.21)	0.57 (0.26-1.25)	0.61 (0.28-1.33)	1	0.297
AA	0.45 (0.10-2.03)	2.59 (0.55-12.24)	0.87 (0.20-3.72)	1	0.282
Hypertriglyceridemia						0.266
GG	0.60 (0.37-0.97)	0.66 (0.42-1.04)	0.53 (0.33-0.84)	1	0.035
GA	0.47 (0.25-0.89)	0.48 (0.26-0.90)	0.56 (0.31-1.02)	1	0.051
AA	0.31 (0.09-1.05)	0.45 (0.12-1.65)	0.60 (0.17-2.12)	1	0.272
Low HDL-C						0.166
GG	0.89 (0.52-1.52)	0.90 (0.53-1.54)	0.78 (0.45-1.34)	1	0.841
GA	1.71 (0.91-3.19)	1.25 (0.66-2.36)	0.86 (0.45-1.66)	1	0.178
AA	2.15 (0.60-7.74)	0.96 (0.21-4.28)	1.60 (0.40-6.41)	1	0.610
High blood pressure						0.876
GG	1.11 (0.67-1.85)	0.89 (0.54-1.45)	0.94 (0.57-1.55)	1	0.865
GA	0.76 (0.41-1.43)	0.66 (0.35-1.24)	0.69 (0.38-1.25)	1	0.530
AA	1.25 (0.29-5.43)	1.22 (0.23-6.52)	0.69 (0.14-3.49)	1	0.893
Hyperglycemia						0.007
GG	0.89 (0.56-1.41)	1.07 (0.68-1.69)	1.44 (0.89-2.34)	1	0.284
GA	0.57 (0.31-1.07)	0.74 (0.40-1.40)	1.11 (0.58-2.13)	1	0.165
AA	0.14 (0.04-0.50)	0.36 (0.09-1.48)	0.52 (0.13-1.98)	1	0.023

^aOdds ratios (95% confidence intervals) for MetS, central obesity, hypertriglyceridemia, low HDL-C, hypertension, and hyperglycemia were estimated by binary logistic regression after adjustment for sex, age (years), body mass index (kg/m²), smoking (current, former, and never), drinking (current, former, and never), vigorous activity (at least once/week or no), and education level (none or elementary school, middle school, and high school or college). HDL-C: high-density lipoprotein cholesterol; MetS: metabolic syndrome. ^bInteraction tests with multiplicative terms were performed to determine whether risks differed between the subgroups.