lncRNA 00312 Attenuates Cell Proliferation and Invasion and Promotes Apoptosis in Renal Cell Carcinoma via miR-34a-5p/ASS1 Axis

Figure 2

Function of lncRNA 00312 was detected in RCC cell lines after overexpression. (a) Efficacy of overexpressing lncRNA 00312 was verified via real-time PCR (). NC: cells transfected empty vector as negative control. (b) lncRNA 00312 inhibited cell proliferation in A498 and ACHN cell lines (). NC: cells transfected empty vector as negative control. (c) lncRNA 00312 inhibited cell invasion in A498 and ACHN cell lines (). NC, cells transfected empty vector as negative control. (d, e) lncRNA 00312 promoted cell apoptosis indicated by TUNEL staining () and Western blot analysis (). NC: cells transfected empty vector as negative control. , , and versus the respective control.

(a)

(b)

(c)

(d)

(e)