miR-155-5p Promotes Oxalate- and Calcium-Induced Kidney Oxidative Stress Injury by Suppressing MGP Expression

Figure 1

Oxalate crystal- and COM crystal-induced renal tubular epithelial cell oxidative stress injury in HK-2 cells. (a–d) Oxalate treatment significantly increased ROS generation, LDH release, cellular MDA levels, and H₂O₂ concentration in HK-2 cells. (e–h) COM crystal treatment significantly increased ROS generation, LDH release, cellular MDA levels, and H₂O₂ concentration in HK-2 cells. (i, j) Western blot and qRT-PCR were used to detect the expression of NOX2 and SOD-2 following the treatment with oxalate and COM in HK-2 cells. and vs. NC group.

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