Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion

<div>Nissl staining of rats’ prefrontal cortex following transient global I/R and cell counting. The prefrontal cortex of control animals (a) did not contain any damaged neurons. However, the cortex of rats in the I/R (b) and I/R+NaCl (c) groups was characterized by fewer Nissl stain neurons (thin arrows) than that in the I/R+Ver group (d) and markedly contained shrunken, intensely stained, and dystrophic neurons (thick arrows). As shown in the graph (e), treatment rats with verapamil significantly reduced neuronal cell loss in the prefrontal cortex. 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109 27V0H384Z"></path></g></svg> vs. I/R+NaCl and I/R groups.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion 

Figure 6 | Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion 