Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells

<div>Proposed mechanism underlying PGE2-induced neurotoxicity in motor neuron-like NSC-34 cells. PGE2: prostaglandin E2; EP2: E-prostanoid receptor-2; EP3: E-prostanoid receptor-3; Gs: Gs protein; Gi: Gi protein; cAMP: cyclic adenosine monophosphate; ROS: reactive oxygen species.</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells 

Figure 9 | Generation of Cellular Reactive Oxygen Species by Activation of the EP2 Receptor Contributes to Prostaglandin E2-Induced Cytotoxicity in Motor Neuron-Like NSC-34 Cells 