AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of Prooxidant/Antioxidant Mechanisms

Figure 8

Insulin signaling cascade in the skeletal muscle of obese Zucker rats. Protein content of total insulin receptor β subunit (IRβ), phosphorylated IRβ at Tyr1150/1151, total insulin receptor substrate 1 (IRS1), and phosphorylated IRS1 at Tyr896, Ser307, and Ser612 with representative Western blots in musculus quadriceps of control obese Zucker rats and in obese Zucker rats receiving AVE0991 via osmotic minipumps for two weeks. The amount of protein was quantified by Western blot method. The signal intensities of the proteins of interest were normalized to the sample’s total protein content stained with Coomassie Brilliant Blue. Data are presented as . Results were analysed by Student’s -test, ; ; .