Research Article

AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of Prooxidant/Antioxidant Mechanisms

Table 3

Insulin signaling cascade in the skeletal muscle of control obese Zucker rats and in obese Zucker rats receiving AVE0991 via osmotic minipumps for two weeks.

RatioObese controlAVE0091Statistics

pIRβ (Tyr1150/1151)/IRβ
pIRS1 (Tyr896)/IRS1
pIRS1 (Ser307)/IRS1
pIRS1 (Ser612)/IRS1

Insulin receptor β subunit (IRβ), phosphorylated IRβ at Tyr1150/1151, total insulin receptor substrate 1 (IRS1), and phosphorylated IRS1 at Tyr896, Ser307 and Ser612 residues.