Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2

Figure 1

Salvianolic acid A protected against high glucose-induced injury in rat RSC96 Schwann cells. (a) After RSC96 cells were treated with various concentrations of glucose for 24 h, cell viability was measured by CCK-8 assay. All data are presented as , . and , compared with glucose 25 mM group. (b) Chemical structure of SalA. RSC96 cells were treated with 150 mM glucose and different concentrations of SalA for 24 h. Cell viability was measured by CCK-8 assay (c) and SRB assay (d). All data are presented as , . , , and , compared with the HG group. qPCR analysis of the Ngf (e), Bdnf (f), P0 (g), and Krox20 (h) gene expression in RSC96 cells treated with 150 mM glucose and different concentrations of SalA for 24 h. All qPCR data are normalized to TBP and presented as , . , , and , compared with the HG group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)