Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway

<div>Verification of CSMC and EC from WTR and TGR and the expression of the hKLK1 in EC by immunofluorescence. Panel (a) shows the verification of CSMC through the expression of desmin (magnification: ×200). Panel (b) shows the verification of EC through the expression of CD31, and hKLK1 was only expressed in EC from TGR but not WTR (magnification: ×100). Panel (c) shows the cell purities of EC and CSMC from WTR and TGR through the bar graph. hKLK1: human tissue kallikrein 1; rKLK1: rat tissue kallikrein 1; WTR: wild-type rats; TGR: transgenic rats; EC: endothelial cell; CSMC: cavernous smooth muscle cell; DAPI: 4<span class="nowrap"><svg height="11.4859pt" id="M55" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>,</span>6-diamidino-2-phenylindole.</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway 

Figure 2 | Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway 