Human Tissue Kallikrein 1 Improves Erectile Dysfunction of Streptozotocin-Induced Diabetic Rats by Inhibition of Excessive Oxidative Stress and Activation of the PI3K/AKT/eNOS Pathway

Figure 3

Erectile response of all rats was evaluated by cavernous nerve electrostimulation. Panel (a) shows representative curves of ICP at 5.0 V. Panels (b) and (c) show the ratios of peak ICP to MAP and total ICP (AUC) to MAP in relation to penile erectile capacity in each group at 2.5 V, 5.0 V, and 7.5 V. Each bar represents . , , and . WTR: wild-type rats; TGR: transgenic rats; WTDM: diabetic wild-type rats; TGDM: diabetic transgenic rats; TGDMH: diabetic transgenic rats administrated with HOE140; ICP: intracavernous pressure; AUC: area under the curve.

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