G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress

<div>G9a regulated hypoxia/reoxygenation-induced proliferation, migration, and oxidative stress in HUVECs. Cultured HUVECs were treated with different concentrations of BIX 01294 (0.1–10 <i>μ</i>M, application 2 h prior to H/R) under normal condition or H/R condition, and cell viability (a) was tested by CCK8 assay. Cell migration was also tested by scratch wound healing (b) and Transwell (c,d) assays. ROS production and H<sub>2</sub>O<sub>2</sub> production were measured after H/R process with treatment with G9a inhibitor or not. 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Experiments were repeated 3 times.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress 