G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress

<div>Treatment with G9a inhibitor for corneal injury induced by the alkali burn 7d. Expression of G9a (a) after treatment with BIX 01294 in mice at concentrations of 5, 10, and 20 mg/kg once daily and quantification of G9a expression in fold change (b) relative to the control group. The cornea picture using a slit lamp, H&amp;E staining, IHC staining for CD31, and CD34 (c), and the number of new vessels (d) were detected after the alkali burn 7 days. 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123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> versus alkali burn. Experiments were repeated 3 times.</div>

Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: G9a Suppression Alleviates Corneal Neovascularization through Blocking Nox4-Mediated Oxidative Stress 