Downregulation of MicroRNA-206 Alleviates the Sublethal Oxidative Stress-Induced Premature Senescence and Dysfunction in Mesenchymal Stem Cells via Targeting Alpl

Figure 2

H₂O₂ treatment induced senescence of MSCs. MSCs under H₂O₂ treatment showed increased percentage of SA-β-gal staining cells () (a, b), reduced percentage of EdU-positive staining cells () (c, d), expanded percentage of early apoptotic cells () (e), shorter relative telomere length (f), and upregulated inflammatory factor (TNF-α and IL-1β) expressions () (g, h) in contrast to normal MSCs. (i) The expression of miR-206 was highly expressed in MSCs under H₂O₂ treatment than in normal MSCs (). , and .

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