Elevated Glutathione Peroxidase 2 Expression Promotes Cisplatin Resistance in Lung Adenocarcinoma

Figure 1

GPX2 expression of in cisplatin- (DDP-) resistant lung adenocarcinoma cell lines and tissues. The expression status of GPX2 in A549/DDP cells and the parental A549 cells was verified at the mRNA (a) and protein (c) levels. (b) GPX2 expression was analyzed in primary tumor cells; 20 LUAD samples were considered to be DDP-sensitive ( mg/L), and 20 samples were considered to be DDP-resistant ( mg/L). (c) Lentiviral vector-meditated shRNAs were used to knock down GPX2 expression in A549/DDP cells, and a GPX2 overexpressed vector was transfected into A549 cells. (d) Western blot analysis of the expression levels of cell cycle and apoptosis-related proteins. and .

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