Potential Protective Effect of Dietary Intake of Non-α-Tocopherols on Cellular Aging Markers Mediated by Tumor Necrosis Factor-α in Prediabetes: A Cross-Sectional Study of Chinese Adults
Table 4
Univariate and multivariate linear regression analyses of different Toc isoforms with cellular aging, oxidative stress, and inflammatory markers in prediabetic individuals.
LTL
mtDNAcn
TNF-α
Log2 (IL-6)
Log2 (8-OHdG)
SOD
β
β
β
β
β
β
Univariate linear regression model
Total Toc
0.001
0.511
0.131
0.220
-0.110
<0.001
-0.001
0.700
-0.005
0.155
-0.012
0.789
α-Toc
-0.0216
0.086
-0.787
0.215
0.301
0.089
0.018
0.269
0.019
0.330
0.303
0.261
β-/γ-Toc
0.010
0.015
0.489
0.018
-0.262
<0.001
-0.003
0.596
-0.009
0.142
-0.050
0.573
δ-Toc
0.021
0.001
0.938
0.005
-0.478
<0.001
-0.009
0.286
-0.014
0.166
-0.113
0.432
Multivariate linear regression model
Total Toc
<0.001
0.978
0.144
0.186
-0.111
<0.001
-0.002
0.378
-0.005
0.178
-0.007
0.861
α-Toc
-0.016
0.188
-0.868
0.187
0.291
0.109
0.019
0.225
0.018
0.382
-0.551
0.044
β-/γ-Toc
0.005
0.222
0.559
0.010
-0.254
<0.001
-0.004
0.427
-0.009
0.174
-0.024
0.779
δ-Toc
0.011
0.063
1.051
0.003
-0.458
<0.001
-0.009
0.295
-0.016
0.142
-0.065
0.634
Multivariate linear regression model adjusted for age, BMI, SBP, DBP, HbA1c, FPG, PG120, UA, TC, TG, HDL-C, and LDL-C as covariates. Abbreviations: Toc—tocopherol(s); LTL—leukocyte telomere length; mtDNAcn—mitochondrial DNA copy number; TNF-α—tumor necrosis factor-α; IL-6—interleukine-6; SOD—superoxide dismutase; GR—glutathione reductase.
