Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP<sup>+</sup>-Induced Toxicity via Progesterone Receptor Signaling

<div>Puerarin ameliorated behavioral impairments in MPTP-lesioned mice. (a) Chemical structure of puerarin. Chemical structure was generated by ChemSketch (<a href="http://www.acdlabs.com/home/">http://www.acdlabs.com/home/</a>). (b) Design for animal experiments. C57BL/6N mice were randomly divided into five groups: control, MPTP, MPTP+Puerarin, MPTP+Progesterone, and MPTP+Puerarin+RU486. Following treatments, the mice were assessed for behavioral impairments and biomarker expression. (c) Rotarod performance test. Animals were evaluated for the riding time. (d) Tail suspension test. Animals were assessed for the immobility time. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP<sup>+</sup>-Induced Toxicity via Progesterone Receptor Signaling 

Figure 1 | Botanical Drug Puerarin Promotes Neuronal Survival and Neurite Outgrowth against MPTP/MPP+-Induced Toxicity via Progesterone Receptor Signaling 