A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms

<div>MAPK and HIF pathway. The ARPE-19 cells were pretreated with 100 <i>μ</i>g/mL of different ingredients for 18 hours before exposed to the light (2900 lx) for 30 minutes, and then protein was extracted from cell lysate and analyzed with Western blot. GAPDH was used as a loading control. (a) Representative blots. (b) Changes of p-p38/p38. (c) Changes of p-JNK/JNK. (d) Changes of p-ERK/ERK. (e) Changes of HIF. 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499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. no light exposure with vehicle (lane 1). Experiments reaped at least three times.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms 