TNFα Mediates the Interaction of Telomeres and Mitochondria Induced by Hyperglycemia: A Rural Community-Based Cross-Sectional Study

Table 1

Clinical and demographic characteristics in groups with different glucose tolerance statuses.

Parameter	NGT ()	AGM ()
Age (years)			≤0.001
Sex, male : female^†	62 : 131	97 : 160	0.120
BMI (kg/m^2)			≤0.001
Waist circumference (cm)			≤0.001
Hip circumference (cm)			≤0.001
SBP (mmHg)			0.004
DBP (mmHg)			0.486
HbA1c%	5.3 (5.1, 5.6)	5.90 (5.5, 6.6)	≤0.001
HOMA-IR	2.22 (1.54, 3.07)	3.23 (2.16, 4.99)	≤0.001
HOMA-β	91.32 (67.99, 130.56)	65.09 (41.08, 98.29)	≤0.001
FPG (mmol/L)	5.46 (5.22, 5.72)	6.57 (6.13, 7.90)	≤0.001
2hPG (mmol/L)	6.03 (5.04, 6.89)	9.7 (7.83, 14.83)	≤0.001
TC (mmol/L)			≤0.001
TG (mmol/L)	1.20 (0.78, 1.66)	1.71 (1.13, 2.36)	≤0.001
HDL-C (mmol/L)	1.29 (1.11, 1.50)	1.25 (1.08, 1.44)	0.050
LDL-C (mmol/L)			≤0.001
GR (U/L)			0.538
SOD activity (U/mL)			0.46
IL-6 (pg/mL)			0.932
TNFα (fmol/mL)			0.977
LTL			0.583
mtDNAcn			0.023

; ; ^†chi-square test. NGT: normal glucose tolerance; AGM: abnormal glucose metabolism; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HOMA-IR: homeostatic model assessment of insulin resistance; HOMA-β: homeostasis model assessment of insulin secretion; FPG: fasting plasma glucose; 2hPG: 2 h postprandial plasma glucose; TC: cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein; LDL-C: low-density lipoprotein; GR: glutathione reductase; SOD: superoxide dismutase; IL-6: interleukin-6; TNFα: tumor necrosis factor α; LTL: telomere length; mtDNAcn: mitochondrial DNA copy number.