Exercise Improves Endothelial Function Associated with Alleviated Inflammation and Oxidative Stress of Perivascular Adipose Tissue in Type 2 Diabetic Mice

Figure 4

Analysis of ROS and/or NO level in PVAT and aorta. (a, b) Representative images and summarized data showing ROS level in PVAT in db/c, db/db, and db/db+exercise mice after 8-week exercise. Scale bar: 50 μm. (c) Representative images showing ROS expression in the aorta; bottom panels are enlarged from the relative box areas of upper panels. Scale bar in the aorta: 200 μm (upper panels) and 50 μm (bottom panels). (d) Summarized data of the ROS level in the aorta in the three groups. (e) Representative images showing NO expression in the aorta. Scale bar in aorta: 40 μm. (f) NO level in aorta from db/c, db/db, and db/db+exercise mice after 8-week exercise; Db/db+exercise: db/db mice performed exercise. , vs. db/c; + , vs. db/db. Data are expressed as . /group.

(a)

(b)

(c)

(d)

(e)

(f)