Metabolomic Analysis of the Ameliorative Effect of Enhanced Proline Metabolism on Hypoxia-Induced Injury in Cardiomyocytes

Figure 1

The expression of the proline-degrading enzyme PRODH is downregulated after MI and hypoxia. (a) Relative expression levels of the proline-degrading enzyme PRODH in 8 nonfailing patients and 8 ischemic HF patients from dataset GSE46224 (). (b) Relative expression levels of the proline-degrading enzyme PRODH between the sham and 1-day, 1-week, or 8-week MI groups from dataset GSE114695 (). (c) Western blot analysis and quantification of PRODH expression in the normoxia control group and the hypoxia group (). (d) Results of quantitative statistical analysis of PRODH expression as measured by RT-qPCR in the normoxia control group and the hypoxia group (). The data are presented as the values. versus the normoxia control group.

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