Metabolomic Analysis of the Ameliorative Effect of Enhanced Proline Metabolism on Hypoxia-Induced Injury in Cardiomyocytes

Table 1

Statistical analysis of 47 differential metabolites from the comparison of the Ad-NC group and the Ad-PRODH group under hypoxia in cardiomyocyte.

Ion mode	Description			VIP	FC	value
Positive	1,2-dioleoyl-sn-glycero-3-phosphatidylcholine	786.60	143.49	7.05	0.90	6.59E-04
	1-Stearoyl-2-arachidonoyl-sn-glycerol	627.53	113.65	6.55	2.27	9.58E-03
	2-Methylbutyroylcarnitine	246.17	242.30	1.05	1.59	7.77E-03
	Acetylcarnitine	204.12	315.31	3.30	0.72	7.71E-04
	Cytidine 5-diphosphocholine (CDP-choline)	489.11	449.49	1.19	0.66	1.33E-03
	D-Proline	116.07	323.98	2.54	0.77	4.70E-02
	Eicosapentaenoic acid	369.17	32.89	4.15	2.00	4.22E-02
	Glutathione disulfide	613.16	573.61	1.62	0.45	1.32E-02
	L-.alpha.-Amino-.gamma.-butyrolactone	102.05	89.49	4.18	5.89	4.38E-02
	L-Aspartate	134.04	421.99	1.48	1.72	3.27E-02
	L-Carnitine	162.11	387.09	1.70	0.66	2.55E-02
	L-Leucine	132.10	323.23	1.85	1.26	5.45E-04
	L-Phenylalanine	166.09	322.60	1.64	1.26	3.08E-04
	Lumichrome	243.09	62.21	1.01	0.88	2.51E-02
	N-Docosanoyl-4-sphingenyl-1-O-phosphorylcholine	809.65	118.37	2.21	2.91	9.87E-04
	Nicotinamide adenine dinucleotide (NAD)	664.12	491.16	1.82	0.37	6.03E-03
	Pantothenate	220.12	278.37	3.10	0.52	6.44E-06
	PC (16 : 0/16 : 0)	756.55	144.77	1.37	0.94	3.98E-02
	Phosphocreatine	212.04	445.88	1.82	0.44	6.92E-05
	Phthalic acid mono-2-ethylhexyl ester	279.16	31.75	4.76	0.88	4.17E-03
	Sphinganine	302.30	125.24	1.37	1.42	1.46E-03
	Taurine	126.02	297.31	5.11	0.81	2.94E-03
	Thioetheramide-PC	758.57	144.77	5.66	0.91	7.10E-04
	Tyramine	120.08	322.71	2.08	1.25	2.95E-04
	1-Methylnicotinamide	137.07	256.68	2.60	0.76	8.53E-02
	1-Oleoyl-sn-glycero-3-phosphocholine	544.34	182.66	1.70	1.19	9.05E-02
	1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine (SOPC)	788.62	37.07	2.47	0.93	5.96E-02
	1-Stearoyl-sn-glycerol; 3-phosphocholine	568.34	184.81	1.35	1.21	6.54E-02
	Creatine	132.08	348.95	1.64	0.61	5.78E-02
	Erucamide	338.34	33.13	4.86	0.86	9.98E-02
	Ile-Thr	233.15	52.99	1.02	0.60	8.87E-02
	Sphingomyelin (d18:1/18 : 0)	731.60	120.65	1.50	1.14	8.86E-02
Negative	2E-Eicosenoic acid	309.28	47.05	2.95	1.31	4.19E-03
	2-Oxoadipic acid	141.02	228.32	6.48	0.47	4.34E-02
	(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid	327.23	35.15	5.34	1.64	8.52E-04
	Arachidonic acid (peroxide free)	303.23	47.62	9.91	1.66	2.94E-02
	Heptadecanoic acid	269.25	35.37	2.03	1.36	2.93E-04
	L-Proline	114.06	324.79	1.12	0.60	2.44E-02
	Myristic acid	227.20	35.15	2.95	1.19	3.11E-02
	N-acetyl-D-lactosamine	442.15	370.14	1.06	0.70	1.06E-02
	Oleic acid	281.25	48.74	11.43	1.27	4.97E-02
	Pantothenate	218.10	279.08	3.31	0.38	1.25E-05
	Pentadecanoic acid	241.22	51.09	3.28	1.28	4.64E-03
	Taurine	124.01	297.53	4.03	0.75	1.23E-03
	1-Palmitoyl-2-oleoyl-phosphatidylglycerol	747.52	51.23	1.10	0.87	8.74E-02
	Cyanuric acid	128.01	59.06	1.72	0.59	5.57E-02
	Dodecanoic acid	199.17	6.28	2.18	1.78	9.90E-02