Effect of Anticancer Quinones on Reactive Oxygen Production by Adult Rat Heart Myocytes

Table 2

Effect of anticancer quinones on cyanide-resistant oxygen consumption by cardiac myocytes. Oxygen consumption was measured with a Clark-type electrode in a 3 ml reaction system at 37°C that contained 125 mM potassium phosphate buffer, pH 7.4, 140 mM NaCl, 10 mM glucose, 5 mM KCN, and viable cardiac myocytes, with or without drugs.

Drug	Oxygen consumption (nmol O2/min/2×10^6 cells)
None	^a
4-Demethoxydaunorubicin
50 μM	^b
400 μM	^b
4-Epidoxorubicin (400 μM)	^b
Menogaril (400 μM)	^b
4-Deoxydoxorubicin (400 μM)	^b
5-Iminodaunorubicin (400 μM)
Mitomycin C
50 μM
400 μM	^b
Mitoxantrone (400 μM)
Menadione
10 μM	^b
50 μM	^b
400 μM	^b

^a of 3 to 5 experiments. ^bSignificantly different from the control, at .