Serum Metabolomics of Early Postoperative Cognitive Dysfunction in Elderly Patients Using Liquid Chromatography and Q-TOF Mass Spectrometry

Table 2

The potential biomarkers of POCD detected by UPLC-Q-TOF/MS and their variation tendency. POCD/non-POCD: POCD group compared to non-POCD group; FC(P/C): fold change of POCD/non-POCD; ↑: upregulated; ↓: downregulated.

RT	Mass	Name	VIP		FC(P/C)	Trend
9.21	250.1205	Ubiquinone-1	2.76		1.95	↑
11.44	427.366	Stearoylcarnitine	1.56		1.20	↑
14.68	283.2875	Stearamide	2.14		1.98	↑
12.69	299.282	Sphingosine	1.72		2.13	↑
0.71	129.0427	Pyroglutamic acid	2.20		0.47	↓
8.95	539.3584	PS(O-20:0/0:0)	1.52		1.71	↑
8.12	511.3273	PS(O-18:0/0:0)	1.52		1.39	↑
8.99	507.2461	PS(17:2(9Z,12Z)/0:0)	3.67		0.10	↓
8.12	978.7156	PI(22:0/22:0)	1.80		1.84	↑
10.72	183.0659	Phosphocholine	2.26		0.50	↓
10.63	399.3349	Palmitoylcarnitine	2.39		1.26	↑
14.63	255.2561	Palmitic amide	1.53		0.41	↓
0.15	256.2406	Palmitic acid	1.40		0.67	↓
5.21	452.3357	PA(O-20:0/0:0)	1.48		1.27	↑
6.18	396.2358	PA(15:0/0:0)	1.49		1.70	↑
13.51	281.2716	Oleamide	1.55		1.97	↑
14.29	383.3398	N-Stearoyl valine	1.51		1.20	↑
9.94	481.3168	LysoPC(15:0)	1.47		1.37	↑
9.60	467.3011	LysoPC(14:0)	1.47		1.48	↑
0.72	131.0946	L-Leucine	1.90		2.47	↑
10.64	423.3348	Linoleyl carnitine	1.60		2.77	↑
0.70	174.1115	L-Arginine	1.51		2.01	↑
4.74	179.0582	Hippuric acid	1.36		0.35	↓
0.74	113.059	Creatinine	1.93		2.25	↑
5.93	148.0375	Citramalic acid	1.50		2.08	↑
7.38	736.7261	CE(24:0)	1.97		2.93	↑
0.71	161.1054	Carnitine	1.85		0.50	↓
12.16	455.3972	Arachidyl carnitine	1.86		1.89	↑
6.48	175.0635	3-Indoleacetic acid	2.06		2.04	↑
10.67	196.1462	2E,4E-Dodecadienoic acid	1.51		0.53	↓
0.72	168.0282	Uric acid	1.70		1.21	↑
7.64	455.1953	PS(6:0/6:0)	2.13		0.17	↓
11.89	549.3038	PS(20:2(11Z,14Z)/0:0)	1.65		2.34	↑
14.14	256.2395	Palmitic acid	2.00		0.72	↓
10.34	450.2617	PA(19:1(9Z)/0:0)	1.73		0.45	↓
1.00	190.0098	Oxalosuccinic acid	1.40		1.47	↑
14.30	282.2553	Oleic acid	1.83		0.70	↓
13.57	280.2398	Linoleic acid	1.85		0.71	↓
0.68	146.0696	L-Glutamine	1.56		0.59	↓
4.73	179.0576	Hippuric acid	1.49		0.30	↓