Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population

Table 3

Baseline correlates of clinical characteristics and cellular aging markers among the 108 participants.

Variables	LTL	mtDNAcn	TNF-α	Log2(IL-6)	8-OHdG	SOD
Sex	—	—	—	—	—	—
Age	0.007	-0.156	0.081	-0.053	0.230	0.193
BMI	-0.058	-0.126	0.114	-0.231	-0.111	-0.025
1/(WC)	-0.005	0.192	-0.140	0.164	0.042	-0.152
HbA1c	-0.169	-0.086	0.278	0.181	-0.012	0.234
FPG	-0.071	-0.124	-0.101	0.000	0.088	0.014
PG30min	-0.187	-0.420	0.200	0.027	0.030	0.130
PG60min	-0.160	-0.191	0.056	-0.030	-0.017	0.153
PG120min	-0.114	-0.057	0.088	0.258	0.014	0.034
NGT or prediabetes	—	—	—	—	—	—
TC	-0.047	-0.104	0.068	-0.048	0.174	-0.038
1/sqrt(TG)	0.069	0.223	-0.146	0.061	0.031	0.072
HDL-C	-0.131	-0.129	-0.007	0.100	0.197	0.079
LDL-C	-0.075	-0.083	0.112	-0.042	0.105	-0.074
UA	-0.196	-0.310	0.216	-0.005	-0.113	0.001
Log2(HOMA-IR)	-0.149	-0.057	0.155	-0.094	-0.204	-0.046
Lg(Matsuda index)	0.208	0.124	-0.197	0.079	0.174	0.013
Log2(HOMA-β)	-0.102	0.030	0.162	-0.125	-0.299	-0.088
1/sqrt(ISSI-2)	-0.133	-0.178	0.060	0.089	-0.076	0.091
LTL	1.000	0.080	-0.304	-0.195	-0.027	-0.268
mtDNAcn	0.080	1.000	-0.359	-0.022	-0.005	-0.213
TNF-α	-0.304	-0.359	1.000	0.125	-0.150	0.369
Log2(IL-6)	-0.195	-0.022	0.125	1.000	0.036	0.137
8-OHdG	-0.027	-0.005	-0.150	0.036	1.000	0.022
SOD activity	-0.268	-0.213	0.369	0.137	0.022	1.000

. . Abbreviations: BMI—body mass index; WC—waist circumference; HbA1c—glycosylated hemoglobin A1c; FPG—fasting plasma glucose; PG—plasma glucose after glucose load in OGTT; NGT—normal glucose tolerance; TC—total cholesterol; TG—total triglyceride; HDL-C—high-density lipoprotein cholesterol; LDL-C—low-density lipoprotein cholesterol; UA—uric acid; ISSI-2—insulin sensitivity index-2; LTL—leukocyte telomere length; mtDNAcn—mitochondrial DNA copy number; TNF-α—tumor necrosis factor-α; IL-6—interleukine-6; 8-OHdG—8-hydroxy-2-deoxyguanosine; SOD—superoxide dismutase.