Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population

Table 4

Spearman’s correlation between baseline cellular aging markers and clinical characteristics at the 3-year follow-up.

Clinical characteristics at 3-year follow-up	Aging markers at baseline
	LTL	mtDNAcn	TNF-α	IL-6	8-OHdG	SOD activity
HbA1c	-0.086	0.065	0.023	-0.098	0.092	-0.010
FPG	-0.008	-0.148	-0.108	-0.138	0.105	-0.073
PG120min	-0.307	-0.113	0.324	0.030	-0.203	0.272
FINS	-0.097	0.013	0.118	-0.164	-0.185	-0.125
INS120min	-0.133	-0.020	0.158	-0.120	-0.180	-0.075
FCP	-0.062	-0.037	0.121	-0.124	-0.206	-0.155
CP120min	-0.273	-0.126	0.251	-0.038	-0.227	0.019
HOMA-IR	-0.066	0.015	0.048	-0.118	-0.129	-0.097
HOMA-β	-0.090	0.080	0.123	-0.032	-0.257	-0.075
TC	-0.208	0.017	0.203	-0.031	0.109	0.020
TG	-0.084	-0.097	0.029	0.049	-0.076	-0.104
HDL-C	-0.079	-0.119	0.163	-0.039	0.104	0.197
LDL-C	-0.138	0.050	0.240	0.003	0.095	0.091
UA	-0.138	-0.181	0.114	-0.004	-0.182	-0.007

. . Abbreviations: HbA1c—glycosylated hemoglobin A1c; FPG—fasting plasma glucose; PG—plasma glucose; INS—insulin; CP—C-peptide; TG—total triglyceride; HDL-C—high-density lipoprotein cholesterol; LDL-C—low-density lipoprotein cholesterol; UA—uric acid; LTL—leukocyte telomere length; mtDNAcn—mitochondrial DNA copy number; TNF-α—tumor necrosis factor-α; IL-6—interleukine-6; 8-OHdG—8-hydroxy-2-deoxyguanosine; SOD—superoxide dismutase.