Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells

<div>ET-1 downregulated the SO<sub>2</sub>/AAT pathway in primary VSMCs. <i>In situ</i> fluorescent staining (blue) detection of endogenous SO<sub>2</sub> in primary VSMCs and quantified average fluorescence intensity by Image J. Fluorescent signal intensity reflects SO<sub>2</sub> levels (a). Protein expression of AAT1 and AAT2 in primary VSMCs (b, c). AAT activity in VSMCs (d). 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AAT1: aspartate aminotransferase 1; AAT2: aspartate aminotransferase 2; ET-1: endothelin-1; VSMCs: vascular smooth muscle cells.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells 

Figure 1 | Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells 