Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells

<div>Involvement of ROS in the ET-1-reduced SO<sub>2</sub>/AAT pathway. <i>In situ</i> fluorescent staining (red) detection of ROS in primary VSMCs and quantified average fluorescence intensity by ImageJ. Fluorescent signal intensity reflects ROS levels (a, b). <i>In situ</i> fluorescent staining (red and blue) detection of endogenous SO<sub>2</sub> in primary VSMCs and quantified average fluorescence intensity by Image J. Fluorescent signal intensity reflects SO<sub>2</sub> levels (c, d). AAT activity in VSMCs and purified protein (e, f). 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ROS: reactive oxygen species; H<sub>2</sub>O<sub>2</sub>: hydrogen peroxide; ET-1: endothelin-1; NAC: N-acetyl-L-cysteine; GSH: glutathione; VSMCs: vascular smooth muscle cells.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells 

Figure 3 | Endothelin-1 Downregulates Sulfur Dioxide/Aspartate Aminotransferase Pathway via Reactive Oxygen Species to Promote the Proliferation and Migration of Vascular Smooth Muscle Cells 