In Search of Zonation Markers to Identify Liver Functional Disorders

Figure 2

Differential distribution profiles of the hepatocyte ploidy. Although a large number of studies have been performed to shed light on the distribution of hepatocyte ploidy, there are still remarkable controversies to date. Some studies demonstrate that the hepatocytes around the pericentral regions are diploid, different from the polyploid hepatocytes around the periportal regions (red line). However, other reports suggest that multinucleated hepatocytes are adjacent to the pericentral regions (blue line). In the meantime, it has been argued that 4c and 8c polyploid hepatocytes localize in the midzone, rather than in the periportal and pericentral regions (green line).