Discoidin Domain-Containing Receptor 2 Is Present in Human Atherosclerotic Plaques and Involved in the Expression and Activity of MMP-2

Figure 3

Protein expression of DDR2 in the aorta and VSMCs. Immunoblot analysis and quantification of DDR2 in aortas of HCD-induced atherosclerotic rabbits ((a); ) and VSMCs that were incubated with various concentrations of 0, 25, 50, and 100 mg/L ox-LDL (b). Data are expressed as the . and vs. the 0 mg group; ^## 100 mg vs. the 25 mg group. Effect of MAPK inhibitors on ox-LDL-induced DDR2 expression (c). VSMCs were preincubated with inhibitors for 30 min and then treated with 100 ng/mL ox-LDL for 24 h in the presence of inhibitors (SP600125, SB203580, and PD98059 against JNK, MEK, and p38 MAPK, respectively). Data are expressed as the . and vs. the ox-LDL group.

(a)

(b)

(c)