The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury

Figure 2

The Pin1 inhibitor, juglone, prevented renal tissue against I/R injury in rats. The model was established with 45 min ischemia and then 24 h reperfusion. (a, b) The effect of juglone at different concentrations (2 mg/kg, 10 mg/kg) on the Cr and BUN levels in the sham group. (c, d) The effect of juglone at different concentrations (2 mg/kg, 10 mg/kg) on the Cr and BUN levels in the I/R group. (e, f) The effect of juglone at different concentrations (2 mg/kg, 10 mg/kg) on Pin1 expression in rats and the quantification. (g, h) The effect of juglone at different concentrations (2 mg/kg, 10 mg/kg) on the structure change was examined by H&E staining and its quantification (×400). (i) The effect of juglone on oxidative stress was examined by DHE staining (×400) (). The values were presented as . vs. the sham group and vs. the I/R group.

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