The Suppression of Pin1-Alleviated Oxidative Stress through the p38 MAPK Pathway in Ischemia- and Reperfusion-Induced Acute Kidney Injury

Figure 4

Pin1 expression and oxidative stress were elevated during the H/R process in vitro. The model was established with 3, 6, and 12 h hypoxia and 6 h reoxygenation. (a) The mRNA was detected by RT-PCR after the H/R process. (b, c) Western blot was used to detect Pin1 expression and the quantification was analyzed. (d–g) The SOD, MDA, ROS, and H₂O₂ levels were detected after H/R injury in vitro (). The values were presented as . vs. the control group.

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