Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival

Figure 1

Regulation of carcinogenesis by ROS. At different ROS levels, cells experience a dichotomous fate. Moderate and low ROS levels tend to promote cell growth and uncontrolled proliferation, thus, promoting carcinogenesis and/or its progression. On the other end of the spectrum, high ROS levels tip the balance to cell death, preventing further growth of the tumor. Figure created with biorender.com.