Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival

Figure 4

Mitochondrial-directed therapeutic strategies. For drugs that target the mitochondrial matrix, components of the electron transport chain and MnSOD are mainly affected, whereas drugs targeting cytosolic regulatory proteins/factors such as the balance between the pro- and antiapoptotic members of the Bcl-2 family affect apoptotic execution. Figure created with biorender.com.