MicroRNA Dysregulation in the Hippocampus of Rats with Noise-Induced Hearing Loss

Table 3

Pathways related to the predicted target genes of differentially expressed miRNAs in noise-induced hearing loss rats.

Term	Regulations	value	Benjamini	Genes
Estrogen signaling pathway	Down	<0.001	0.001	Adcy6	Creb1	Creb5	Kcnj9
Vasopressin-regulated water reabsorption	Down	<0.001	0.006	Adcy6	Creb1	Creb5
Thyroid hormone synthesis	Down	<0.001	0.009	Adcy6	Creb1	Creb5
Aldosterone synthesis and secretion	Down	0.001	0.009	Adcy6	Creb1	Creb5
Insulin secretion	Down	0.001	0.009	Adcy6	Creb1	Creb5
Circadian entrainment	Down	0.001	0.009	Adcy6	Creb1		Kcnj9
Insulin resistance	Down	0.001	0.009		Creb1	Creb5		Pten
Cholinergic synapse	Down	0.001	0.009		Creb1	Creb5	Kcnj9
Dopaminergic synapse	Down	0.002	0.011		Creb1	Creb5	Kcnj9
cGMP-PKG signaling pathway	Down	0.003	0.013	Adcy6	Creb1	Creb5
cAMP signaling pathway	Down	0.004	0.018	Adcy6	Creb1	Creb5
PI3K-Akt signaling pathway	Down	0.011	0.050		Creb1	Creb5		Pten
TNF signaling pathway	Down	0.055	0.170		Creb1	Creb5
AMPK signaling pathway	Down	0.064	0.190		Creb1	Creb5
Wnt signaling pathway	Up	0.071	1.000	Dvl3	Nfatc3