Exercise-Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression

Figure 3

Swimming and exogenous irisin improved cognitive impairment in mice with MCAO. The experimental design was shown for the evaluation of the cognitive function of mice (a). Mice in different groups were tested in the Morris water maze test (b–d), in an open field test (e, f), a novel object recognition task (g), and a fear conditioning test (h–k). Data are expressed as , per group, vs. S,^# vs. MCAO, vs. SW+ control IgG.

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