Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization

Table 1

Characteristics of the studied insomnia-associated SNPs in both insomnia and PUD GWAS.

SNP	Gene	EA	NA	Insomnia results			PUD results
				BETA	SE		BETA	SE
rs375216017	MEIS1	GT	G	0.089574	0.015720		—	—	—
rs62144051	MEIS1	G	A	0.096151	0.016318		0.018165	0.019416	0.35
rs62144053	MEIS1	A	G	0.098931	0.016272		0.026932	0.019223	0.16
rs62144054	MEIS1	A	G	0.097846	0.016237		0.026976	0.019221	0.16
rs113851554	MEIS1	T	G	0.178239	0.020371		0.019566	0.025498	0.44
rs182588061	MEIS1	T	G	0.228449	0.036320		0.029322	0.051821	0.57
rs139775539	MEIS1	A	AC	0.186994	0.022403		—	—	—
rs11679120	MEIS1	A	G	0.187813	0.022461		0.021005	0.027931	0.45
rs115087496	MEIS1	C	G	0.177042	0.022576		0.009710	0.029911	0.73
rs549771308	MEIS1	C	CT	0.090546	0.015777		—	—	—
rs11693221	MEIS1	T	C	0.170821	0.022572		0.009066	0.028027	0.75
rs574753165	SCFD2	G	A	0.394740	0.067503		—	—	—

PUD: peptic ulcer disease; EA/NA: effect allele/no effect allele; BETA: effect size; SE: standard error of the effect size; : values indicate genome-wide significance in GWAS.