Research Article

[Retracted] Screening and Identification of Antidepressant Active Ingredients from Puerariae Radix Extract and Study on Its Mechanism

Table 2

Antidepressant targets of active components from Puerariae Radix.

GeneTarget name

NOS2Nitric oxide synthase 2
CHRM1Cholinergic receptor muscarinic 1
ESR1Estrogen receptor 1
ARAndrogen receptor
PTGS2Prostaglandin-endoperoxide synthase 2
PDE3APhosphodiesterase 3A
ADRA1DAdrenoceptor alpha 1D
SLC6A3Solute carrier family 6 member 3
ADRB2Adrenoceptor beta 2
SLC6A4Solute carrier family 6 member 4
ESR2Estrogen receptor 2
DPP4Dipeptidyl peptidase 4
MAPK14Mitogen-activated protein kinase 14
GSK3BGlycogen synthase kinase 3 beta
HSP90AA1Heat shock protein 90 alpha family class A member 1
MAOBMonoamine oxidase B
ACHEAcetylcholinesterase (Cartwright blood group)
JUNJun protooncogene, AP-1 transcription factor subunit
IL4Interleukin 4
SIRT1Sirtuin 1
CHRM3Cholinergic receptor muscarinic 3
KCNH2Potassium voltage-gated channel subfamily H member 2
SCN5ASodium voltage-gated channel alpha subunit 5
HTR3A5-Hydroxytryptamine receptor 3A
ADRA1BAdrenoceptor alpha 1B
NCOA2Nuclear receptor coactivator 2
DRD1Dopamine receptor D1
CHRM4Cholinergic receptor muscarinic 4
HTR2A5-Hydroxytryptamine receptor 2A
CHRM2Cholinergic receptor muscarinic 2
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit
OPRM1Opioid receptor Mu 1
GABRA1Gamma-aminobutyric acid type A receptor subunit alpha1
BCL2BCL2 apoptosis regulator
BAXBCL2-associated X, apoptosis regulator
CASP9Caspase-9
CASP3Caspase-3
TGFB1Transforming growth factor beta 1
PON1Paraoxonase 1
MAP2Microtubule-associated protein 2
GRIA2Glutamate ionotropic receptor AMPA type subunit 2
NCOA1Nuclear receptor coactivator 1
STAT3Signal transducer and activator of transcription 3
AKT1AKT serine/threonine kinase 1
VEGFAVascular endothelial growth factor A
FOSFos protooncogene, AP-1 transcription factor subunit
CD40LGCD40 ligand
NFKBIANFKB inhibitor alpha
SOD1Superoxide dismutase 1
HIF1AHypoxia-inducible factor 1 subunit alpha
FASFas cell surface death receptor
VCAM1Vascular cell adhesion molecule 1
PLATPlasminogen activator, tissue type
CYP19A1Cytochrome P450 family 19 subfamily A member 1
GSTP1Glutathione S-transferase Pi 1
SELPSelectin P
AGTR1Angiotensin II receptor type 1
AKR1B1Aldo-keto reductase family 1 member B
IFNB1Interferon beta 1
GPTGlutamic--pyruvic transaminase
PGPPhosphoglycolate phosphatase
IFNA1Interferon alpha 1
LEPRLeptin receptor
F2RCoagulation factor II thrombin receptor