[Retracted] Screening and Identification of Antidepressant Active Ingredients from Puerariae Radix Extract and Study on Its Mechanism

Table 3

Core antidepressant targets of Puerariae Radix and their topological characteristics.

Core gene	Target name	Degree	Betweenness centrality
AKT1	AKT serine/threonine kinase 1	33	0.1808849
FOS	Fos protooncogene, AP-1 transcription factor subunit	28	0.12839175
CASP3	Caspase-3	27	0.05017522
JUN	Jun protooncogene, AP-1 transcription factor subunit	25	0.04969618
VEGFA	Vascular endothelial growth factor A	25	0.0346735
STAT3	Signal transducer and activator of transcription 3	24	0.02416106
PTGS2	Prostaglandin-endoperoxide synthase 2	22	0.01342578
MAPK14	Mitogen-activated protein kinase 14	20	0.00748504
ESR1	Estrogen receptor 1	19	0.00626354
SIRT1	Sirtuin 1	19	0.01170971
HSP90AA1	Heat shock protein 90 alpha family class A member	18	0.04733413
ACHE	Acetylcholinesterase (cartwright blood group)	18	0.07253423
SOD1	Superoxide dismutase 1, soluble	17	0.02514393
HIF1A	Hypoxia-inducible factor 1 alpha subunit	17	0.00556528
AR	Androgen receptor	16	0.0133448