Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

Figure 3

CIH induces ROS generation and the loss of VSMCs in vivo. An animal model of AAA was established by infusion Apoe^-/- mice with Ang II. The mice in the control group were infused with same volume of saline. Mice were then exposed to CIH condition for 4 weeks. (a) Representative image of DHE and TUNEL staining. (b) Quantification result of DHE staining (). (c) Quantification result of TNUEL staining (). (d) Representative image of immunohistochemical. (e) Quantification of cleaved caspase-3-positive area from immunohistochemical (). (f) TEM images (30000×) for the mitochondria of mouse aortic VSMCs. (g) Representative image of Western blot. (h) Quantification of Bax, Bcl-2, and cleaved caspase-3 protein expression (). , , and .

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