Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice

Figure 6

The schematic diagram of signal pathway was displayed. rCTRP9 binding to the COOH terminal of AdipoR1 and the intracellular NH2 terminal of AdipoR1 will bind to PTB domain of APPL1, activated APPL1 can activate AMPK phosphorylation, p-AMPK make Nrf2 release from the complex and accumulate in the cytoplasm, and then activated Nrf2 translocate into the nucleus and bind to ARE in a battery of antioxidative genes against oxidative stress.