Mangiferin Inhibits PDGF-BB-Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK/Drp1 Axis

Figure 5

Mangiferin significantly suppressed PDGF-BB-induced RSMC phenotype transformation through the AMPK/Drp1 axis. (a, b) AMPK inhibitor, compound C, reverses the inhibitory effects of mangiferin on PDGF-BB-induced mitchondrial fission. (c, d) The protein expression levels of Drp1, and pDrp1^Ser616 was determined using western blot after RSMCs were treated with or without PDGF-BB, mangiferin, and compound C.

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