[Retracted] Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice

Figure 4

OST inhibits TGF-β1-induced Smad3 activation, fibroblast differentiation, collagen synthesis, and proliferation in lung fibroblasts. (a) Level of p-Smad3 and total Smad3 in MRC-5 cells treated with TGF-β1 (10 ng/mL) and OST (1-50 μM) for 24 h (). (b) Expression of α-SMA, CTGF, collagen I, and collagen III in MRC-5 cells treated with TGF-β1 (10 ng/mL) and OST (1-50 μM) for 24 h (). (c) Proliferation of MRC-5 cells treated with TGF-β1 (10 ng/mL) and OST (1-50 μM) for 48 h (). vs. control; ### vs. TGF-β1.

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