The Potential Effects of Oxidative Stress-Related Plasma Abnormal Protein Aggregate Levels on Brain Volume and Its Neuropsychiatric Consequences in Parkinson’s Disease
Table. 1
Demographic characteristics of PDN patients, PDCD patients, and control subjects.
Normal control
PDN
PDCD
value
Total
PDN vs. PDCD
Number
24
13
18
Gender (M : F)
6 : 18
7 : 6
5 : 13
0.182
0.131
Age
0.489
0.302
Education (years)
0.003
0.012
UPDRS I
N/A
0.937
UPDRS II
N/A
0.045
UPDRS III
N/A
0.149
UPDRS 176
N/A
0.089
Modified Hoehn and Yahr staging
N/A
0.379
Schwab and England (S&E) scale
N/A
0.859
Levodopa equivalent daily doses (mg)
N/A
0.02
Plasma abnormal protein aggregates levels (pg/mL)
NfL
<0.001
0.048
T-tau
0.001
0.350
AB42
0.035
0.085
AB40
<0.001
0.083
Alpha Synuclein
<0.001
0.052
Wechsler Adult Intelligence Scale-III (WAIS-III)
Picture completion
0.002
0.035
Vocabulary
<0.001
0.005
Digit symbol-coding
<0.001
0.002
Similarities
<0.001
0.007
Block design
<0.001
0.016
Arithmetics
<0.001
<0.001
Matrix reasoning
0.006
0.008
Digitspan
<0.001
<0.001
Information
<0.001
0.147
Picture arrangement
0.007
0.203
Comprehension
<0.001
0.005
Letter-number sequencing
0.037
0.010
Age and gender data were compared by ANOVA test. Misfolding protein biomarkers were compared by analysis of covariance (ANCOVA) after controlling for age and gender. Wechsler Adult Intelligence Scale-IV was compared by analysis of covariance (ANCOVA) after controlling for age, gender, and education. Data are presented as ..
