Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway

<div>Overexpression and knockdown of FAF1 regulated the expression of glucose metabolism genes. (a, b) The mRNA and protein levels of FAF1 after knockdown and overexpression of FAF1 in HepG2 cells. (c) Knockdown of FAF1 downregulated <i>G6PC</i> expression but upregulated <i>GLUT2</i> expression in HepG2 cells. (d) Overexpression of FAF1 upregulated <i>PEPCK</i> and <i>G6PC</i> expression but downregulated <i>GLUT2</i> expression in HepG2 cells. (e, f) The mRNA and protein levels of FAF1 after knockdown and overexpression of FAF1 in SK-HEP-1 cells. (g) Knockdown of FAF1 downregulated <i>PEPCK</i> and <i>G6PC</i> expression but upregulated <i>GLUT2</i> expression in SK-HEP-1 cells. (h) Overexpression of FAF1 upregulated <i>PEPCK</i> and <i>G6PC</i> expression but downregulated <i>GLUT2</i> expression in SK-HEP-1 cells. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway 