Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway

<div>FAF1 regulated insulin signaling pathway via JNK. (a, b) FAF1 deficiency decreased JNK phosphorylation, and FAF1 overexpression increased JNK phosphorylation in HepG2 and SK-HEP-1 cells. (c, d) SP600125 (10 <i>μ</i>M), a JNK signaling inhibitor, restored the aberrant insulin signaling induced by FAF1 overexpression in HepG2 and SK-HEP-1 cells. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK Signaling Pathway 