TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization

Figure 2

Myeloid-specific TL1A overexpression exacerbates steatohepatitis. (a) Representative liver H&E staining and histological scores of steatosis and inflammation of liver sections of mice with fed HFHF and MCD diets were showed (200x). (b1) Lipid droplets in liver sections of mice with fed HFHF and MCD diets were detected by Oil Red staining (200x). Hepatic cholesterol content (b2) and triglyceride content (b3) in mice of HFHF model and triglyceride content (b4) in mice of MCD model were test. (c1, c2) Serum ALT and AST in mice of HFHF model were measured. (c3, c4) Serum ALT and AST in mice of MCD model were measured. (d1) The percentage of apoptotic hepatocytes in mice of HFHF or MCD model was measured by TUNEL (400x). (d2) The expression of cleaved-caspase3 and cleaved-PARP in mice of HFHF and MCD model was detected by Western blotting to verify the level of apoptotic hepatocytes. Data are expressed as , , , .

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