The Knockdown of Nrf2 Suppressed Tumor Growth and Increased the Sensitivity to Lenvatinib in Anaplastic Thyroid Cancer

Figure 6

The knockdown of Nrf2 increased the sensitivity of lenvatinib in FRO and KAT-18 cells. (a) The 24 h IC50 of lenvatinib in FRO-shNrf2 and control cells was determined by MTT assay. The knockdown of Nrf2 decreased the IC50 value in FRO cells. A similar method was used to detect the IC50 of lenvatinib in KAT-18-shNrf2 and control cells, and the results showed that knockdown of Nrf2 decreased the IC50 value in KAT-18 cells. (b) Lenvatinib inhibits the expression of Nrf2 in FRO and KAT-18 in a dose-dependent manner.

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